Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator
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چکیده
منابع مشابه
Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator
PURPOSE The effects of amiloride on cellular toxicity caused by tissue plasminogen activator (tPA) in mouse primary retinal cells were investigated. METHODS Primary retinal cell cultures were maintained using glial conditioned medium. Commercial tPA and L-arginine were added, and the level of cyclic guanosine monophosphate (cyclic-GMP) in the culture supernatant was assessed using an ELISA as...
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BACKGROUND The efficacy of fibrinolytic therapy is limited by the small surface area of the clot that is available for the binding of the thrombolytic agent, such as tissue-type plasminogen activator (t-PA). We hypothesized that exposure of the clot to ultrasound during thrombolytic treatment could enhance lysis through perturbation of the thrombus, which would expose additional fibrin binding ...
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Ultrasound reversibly alters the structure of polymerized fibrin, an effect that could influence tissue-plasminogen activator (t-PA) binding. We have, therefore, characterized the effects of ultrasound on binding of t-PA to fibrin using a novel system in which radiolabeled, active-site blocked, single chain tissue-plasminogen activator flowed through a fibrin gel at constant rate, and specific ...
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ژورنال
عنوان ژورنال: Korean Journal of Ophthalmology
سال: 2012
ISSN: 1011-8942,2092-9382
DOI: 10.3341/kjo.2012.26.5.378